Atezolizumab as a first line treatment for triple negative breast cancer

Atezolizumab immunotherapy for triple negative brest cancer

FDA approved under an accelerated program using Atezolizumab (Tecentriq) and Nab-Paclitaxel (a combination of immunotherapy with chemotherapy). This combination, as the first-line treatment, increases the overall survival in patients with triple negative breast cancer (TNBC). In fact, it is the first immunotherapy approved for this diagnosis.

Recent studies prove promising immunotherapy with atezolizumab

Results of the Impassion130 study were presented at the conference of the European Society of Medical Oncology (ESMO) and the Меdical Journal of New England. 902 patients took part in this study.

Women were divided into two groups equally by 451 persons. All the women were previously diagnosed with advanced or metastatic triple negative breast cancer. Atezolizumab with Nab-Paclitaxel or placebo with Nab-Paclitaxel were prescribed to them.

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Immunotherapy for triple negative breast cancer increases survival

Survival in groups with immunotherapy, and with standard treatment:

  • intraoperative progression-free – 7.2 versus 5.5 months, the risk ratio is 0.80, p = 0.0025;
  • overall median survival was noted, but without statistical significance during interim analysis.

Atezolizumab efficacy with positive PD-L1

In subgroups with positive PD-L1, or with increased expression of immune cells equal to or greater than 1%:

  • Atezolizumab was prescribed to 185 women,
  • Placebo – to 184.

It was notes reduction in mortality risk as well as an increase in survival in the immunotherapy group compared with standard treatment:

  • Progression risk – 7.5 vs. 5.0 months, the risk coefficient is 0.62, p <0.0001.
  • The overall median survival – 25 versus 15.5 months, the risk coefficient is 0.62, respectively.

During the study, the disease was diagnosed or progressed:

  • in Tecentriq group – 358 patients, or 79%;
  • in placebo group – 378 women, or 84%.

The most common adverse events noted by researchers:

  • neutropenia (8%),
  • peripheral neuropathy (6%),
  • decreased neutrophil count (5%),
  • fatigue (4%)
  • anemia (3%)

Adverse events were recorded in both groups, while no new problems were noticed in the immunotherapy group.

Source: E-med, Israel.

 

Consultation with the Head of the Breast Cancer Institute

Contact us for a professional opinion from a leading Israeli breast cancer expert.Send your medical history and test results (biopsy report, PET-CT, MRI, disks) — we will provide the consultation details and cost, and, if possible, a suggested treatment plan.The consultation can be arranged remotely at any stage of the disease. 

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Профессор Тамар СафраProf. Tamar Safra, MD, PhD - Head of the Department of Gynecologic Oncology and Breast Cancer, Sourasky Medical Center (Ichilov). Online consultation.
Доктор Ноа Эфрат Бен Барух, MD - ведущий онколог по лечению рака молочной железыDr. Noa Efrat Ben Baruch, MD - Expert in the treatment of breast cancer and HER2 mutations. Former Director of the Oncology Institute at Kaplan Medical Center in Rehovot
Проф. Ринат Ерушалми - онколог по раку груди в ИзраилеProf. Rinat Yerushalmi – Director of the Breast Oncology Department at the Davidoff Center, Beilinson Hospital, Rabin Medical Center.

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During the consultation, the following is discussed:

    • Medications and treatment protocols according to tumor type and BRCA mutation status
    • Personalized treatment based on tumor sensitivity testing to all existing medications
    • Options for receiving treatment in Israel
    • Interpretation of PET-CT and histology results
    • Eligibility for clinical trials
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*The content of this page is for informational purposes only and is not considered medical advice, a professional opinion, or a substitute for consulting a specialist in any field. If you have any medical concerns, you should consult a doctor.

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