Early diagnosis of cancer
Early detection of malignant diseases is very important for the further successful treatment and lives save. Such issues in Israel are engaged in the direction of looking into genetic disorders.
Our doctors perform genetic testing to identify high-risk malignancies.
In the case of suspicion of a congenital defect which can lead to a high probability of malignant disease in the family (several kinds of the same type of cancer in the family: a few relatives with malignant tumors, the incidence at a young age, and so on) our doctors perform study for the mutations in the genes responsible for malignant diseases. Genetic testing can prevent or allow to identify malignant disease at an early stage, as well as to find the therapeutic decision.
The patient should get consultation of genetics who will determine the next steps, as well as the need to perform DNA testing. Depending on the results of the consultation doctor can also give recommendations for first degree relatives of the patient with a definite program of observation and genetic tests, if required.
In some cases, for performing a genetic test only sample the patient’s blood or saliva is needed. Laboratory test results are known, usually within two – six weeks.
⇒ Oncotests for heredity detection and precision treatment used in Israel
1. Diseases and genetic syndromes that cause a high risk of malignant diseases for which genetic testing is a good solution for early detection:
Family adenomatous polyposis (APC)
Syndrome von Hippel-Lindau (VHL)
Medullary thyroid carcinoma (RET)
2. Early diagnosis of breast cancer
Women aged 50 years are recommended to do mammography 1 every two years.
Women, aged 40 years, who had a history of benign breast disease with atypia, are recommended to do mammography every year.
For women at high risk screening test it is recommended breast MRI – in accordance with the recommendations of the Ministry of Health.
Clinical breast examination is not a test for the detection of breast cancer, it is part of a general physical examination. Breast self-examination is not an effective test for the early detection of breast cancer.
3. Early diagnosis of cancer of the colon and rectum
At the age of 50 years for patients with normal risk we recommend an annual highly sensitive test for the detection of fecal occult blood.
At the age of 40 cases of patients with a diagnosis of colon cancer first-degree relatives in the family, it is recommended to do colonoscopy once every five years.
Patients with the syndrome case of colon cancer is not Polifozi (HNPCC / Lynch syndrome) in first-degree relatives, are recommended to undergo annual colonoscopy at age 25 years and older.
Patients with the syndrome case of colon cancer Polifozi in first-degree relatives are recommended to undergo annual colonoscopy at age 15 years and older.
Patients with inflammatory bowel disease (Crohn’s disease, ulcerative colitis) are recommended to undergo periodic colonoscopy, in accordance with doctor’s advice.
4. Early detection of lung cancer
In total, there is no any specific indicators to perform standard screening and scanning for the early detection of lung cancer. Nevertheless, those who are exposed to asbestos, it is recommended conducting X-ray 1 time a year.
5. Early detection of ovarian cancer
Clear indications for routine screening for early detection of ovarian cancer does not exist.
Women belonging to vulnerable groups are recommended to consult with a physician-geneticist in cases of personal or family history of breast cancer diagnosed before the age of 50 years, in the case of a family history of ovarian cancer, as well as personal or family history of colon cancer and endometrial cancer diagnosed before the age of 50.
Foe women who are on the results of genetic tests identified high risk of developing ovarian cancer it is recommended to undergo periodic examination (every 6 months) at the age of 25, including a gynecological examination, vaginal ultrasound, with or without CA-125 test.
6. Early diagnosis of cervical cancer
There is no any specific recommendations for the early detection of cervical cancer. However, women need to perform smear test every three years, between the ages of 25 to 65.
7. Early detection of melanoma and skin cancer
There are no specific recommendations for the implementation of the common screening tests for the early detection of melanoma and skin cancer.
For people at high risk of skin cancer or melanoma it is important to inform family members about the disease, and to carry out periodic self-evaluation after the defeat of the skin disease, as well as perform periodic skin examinations by dermatologist or plastic surgeon.
Groups at high risk of melanoma or skin cancer exposure to ionizing radiation for the treatment of ringworm in childhood, history of melanoma in first-degree relatives, presence of atypical moles, including family members of the first-degree relatives.
8. Early detection of prostate cancer
There are no any specific recommendations for the implementation of the common screening tests for the early detection of prostate cancer. Digital rectal examination is an essential part of the general physical examination for the early detection of prostate cancer.
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