Caris Molecular Intelligence is an analysis of a cancerous tumor at the molecular level that helps to make the most detailed profile of the malignant tissue, on the basis of which our oncologists can recommend to the patient drugs actually effective on his tumor, and also to determine the list of drugs that will not be effective.
In order to select an individual effective treatment protocol for your cancer, only genomic mapping (identification of genes responsible for the spread of cancer of the tumor (NGS / Next Generation Sequencing) is not enough. Therefore, it is is recommended a comprehensive molecular study that helps to direct treatment according to your unique genomic and biological characteristics.With a comprehensive analysis of genomic and biological information obtained from your tumor sample, test Caris Molecular Intelligence ® probe finds the molecular “fingerprint” of your tumor. This “fingerprint” is created by identifying biomarkers in your tumor at the level of genetic material (RNA and DNA) and the level of proteins in the tumor that provide extensive information about the tumor’s ability to respond to specific drugs.
Cancer biomarkers are usually proteins, genes and other molecules at the genetic and molecular level that affect the growth of cancer cells, the way they grow and how they react to other compounds in the body.
Due to its quality and innovation Caris test is a confident basis for personalized medicine. It combines extensive laboratory testing with clinical studies on biomarkers to help clinicians evaluate potential drug or clinical benefits as well as adaptation of immunotherapy (Keytruda, Opdivo, Yervoi, etc.). Through gene testing Caris reveals the load of the TML gene and genomic instability in the MSI tumor indices, which help to predict whether a given tumor will respond to immunotherapy.
In addition, proteins are tested in a tumor. Immunohistochemical analysis (IHC), which determines the level of expression of proteins, also includes testing of PD-L1 for immunotherapy. For each patient it is compiled a report which can help doctors to develop a treatment plan for a specific tumor.
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⇒ What is precision cancer treatment?
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