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lymphoma

 

 

Lymphoma is a cancer of lymphatic system, in which the T and B lymphocytes as part of the immune system designed to protect the body against infections and diseases start to divide faster than normal, or their life expectancy is becoming longer than anticipated nature.

 

For each specific type of disease we select a narrow field haematologist, which makes the most effective treatment and help improve the life quality of our patients.

 

Leading experts on the treatment of diseases of the circulatory and lymphatic systems in Israel are:

 

Prof. Ofer Spielberg – Head of the Hematology Department at Assuta, Tel Aviv. Professor at the Faculty of Medicine at the University of Ariel.

 

Prof. Ella Naparstek – The main clinical practice of the professor in the field of malignant hematological diseases (leukemia, lymphoma, myeloma), bone marrow transplantation and cancer immunotherapy.

 

Dr. Odelia Gur – a specialist in hematology (blood cancer, lymphoma) and bone marrow transplantation, Head of Department of a day hospital, Ichilov Hospital.

 

If you or any of your relatives were diagnosed with such disease, please contact us. We accept patients for the treatment of all disease stages, any kind of tumor location and malignancies in the body.

 

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Lymphoma may develop in the lymph nodes, spleen, bone marrow, blood or other organs, gradually forming a lymphoid tumor cell.

 

The main symptoms of the disease increase inflammation of the lymph nodes, sometimes accompanied by itching, fever, night sweats.

 

There are two main types of disease – Hodgkin’s and non-Hodgkin’s lymphoma. There are also lymphoma low-grade and high-grade. In the case of disease with a low degree usually without symptoms do not require the initial treatment. Need constant supervision of an experienced physician who will prescribe proper treatment.

 


Lymphoma types

Lymphoblastic leukemia – a disease in 40 % of cases develop in children.

 

Follicular lymphoma (SS / CB, or nodular lymphoma syndrome Brill – Simmersa ) – one of the most common types of non-Hodgkin’s lymphoma occurs in 40 % of the adult population.

 

Diffuse B-cell lymphoma – non-Hodgkin’s lymphoma view strikes usually elderly, mainly in the age of 70, rarely children and young people. The disease responds well to treatment competently chosen chemotherapy.

 

Mantle cell lymphoma (MCL) – a rare form of non-Hodgkin lymphoma occurs in 6 % of cases from all kinds of diseases.

 

Chronic lymphocytic leukemia – the most common in men older than 50 years, handed down to children.

 

MALT lymphoma (MALToma) is a form of lymphoma involving the mucosa associated lymphoid tissue (MALT), often the stomach, but can suffer almost any organ mucosa.

 

Burkitt’s lymphoma (or “Burkitt’s tumor”, Burkitt’s lymphoma or “Malignant lymphoma, Burkitt’s type”) is a type of cancer of the lymphatic system, a high degree of aggression.

 

Mycosis fungoides (or granuloma syndrome aliber – Bazin) – the most common type of lymphoid system which affects the skin.

 

Peripheral T- cell lymphoma – one of the most aggressive forms of non-Hodgkin ‘s lymphoma, which affects the two individual leukocyte types – B cells and T cells, causing them to develop properly. There are two types of this kind of disease – T-zone lymphoma and lymphoepithelial lymphoma (Lennert’s type)

 

Nodular sclerosis (chlamydia) – the most common form of Hodgkin’s lymphoma which occurs in young adults, mostly from 28 years.

 

Mixed-cell lymphoma – the second most common type of Hodgkin’s disease which is found in men and in most cases, associated with Epstein-Barr virus.

 


Lymphoma diagnosis

  • Blood test
    PET-CT
    Biopsy + histological examination
    Consultation with a hematologist

 


Lymphoma treatment

Prognosis and treatment of this disease is different for Hodgkin’s lymphoma and non-Hodgkin all kinds and also depends on the aggressiveness of the disease. Paradoxically, the disease with a high degree of malignancy is more treatable and have a successful prediction.

 


Treatment methods:

 

Method of treatment is determined by the physician based on the results of the medical tests in Israel.

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T-cell lymphoma

T-cell lymphoma (or T-lymphoblastic lymphoma) occurs when lymphocytes change which affects division and proliferation of these cells. This process leads to the formation of increasing numbers of abnormal cells.

Leading experts on the treatment of diseases of the circulatory and lymphatic systems in Israel are:

Dr. Odelia Gur – a specialist in hematology (blood cancer, lymphoma) and bone marrow transplantation, Head of Department of a day hospital, Ichilov Hospital

Professor Gideon Rechavi – a specialist in the treatment of children’s oncology, brain tumors and leukemia, Director of the Research Cancer Center, Sheba Medical Center, Tel Hashomer

Professor Isaac Yaniv – expert in pediatric oncology and bone marrow transplantation, Director of Hematology Schneider Children’s Hospital

The process of lymphoma formation can start in any of the lymph nodes as well as in spleen, intestine, thymus and bone marrow. Moreover, after the start of the process lymphoma cells migrate to all parts of the lymphatic system, thereby providing the spread of tumors. When the process goes to the lymph nodes they are due to increased multiplication of cancer cells.

It is also important to note the growth of the lymph nodes, which in most cases do not occur because of the disease, as is the normal response of the immune system, which aims to produce a larger number of lymphocytes to fight infection.

Lymphoma is a common form of cancer in children. About a fifth of all childhood cancers is lymphoma. There are several types of lymphomas in children. Common type – Hodgkin’s lymphoma, B-cell lymphoma and T-cell lymphoma. Every year in Israel diagnosed about fifty new cases of lymphoma in children.

There is still no scientific explanation as to why the child develops cancer. The disease is not inherited in most cases. The disease does not occur due to environmental factors are known (ie – no proven connection between exposure and the development of lymphoma because of the use of mobile phones, power lines, food or anything else). There are scientific theories that connect the various viruses and lymphoma, but on this occasion there is no clear information.

Symptoms of lymphoma may include swollen lymph nodes (the most common sites of neck and chest – the thymus gland), enlargement of the spleen and liver, fever, fatigue, weakness, weight loss and sweating at night.

Diagnosis of lymphoma
Diagnosis includes blood tests, as well as microscopic study (analysis of tissue samples taken from suspicious enlarged nodes). Selection is carried skilled tissue as the biopsy procedure (sometimes operating method under CT) followed by a microscopic examination is performed and accurate determination process and the type of tumor.
PET – CT – positron emission computed tomography can detect cancer cells in enlarged lymph nodes or organs, and thus determine the stage of the disease.
Bone marrow (performed under anesthesia) – Samples taken from the bone marrow, usually in the pelvis.

Lymphoma treatment
Like all cancers, lymphoma associated with cell proliferation and division. Therefore, treatment is based on methods that cause the death of dividing cells. The basic tool is the use of chemotherapy. In rare cases, a surgery to remove the tumor, may also be used radiotherapy.
Complete cure of cancer requires complete removal of all existing in the patient’s cancer cells. If the result of the treatment will be even a small amount of lymphoma cells, the disease will develop and propagate in the body For this reason, the treatment takes a long time. Treatment normally includes a combination of drugs that “beating” cancer cells in several ways. This method reduces the risk of resistance of cancer cells to treatment. Chemotherapy may be given in the form of tablets, syrups or injections directly into the blood stream through a vein.
Furthermore, in some cases there is need to inject drugs into cerebrospinal fluid (the fluid that surrounds the brain and spinal cord), which allows preparations freely penetrate directly into the cerebrospinal fluid. This procedure is performed about 11 times during the treatment of lymphoma.

Radiotherapy is a process in which the treatment is directed at the tumor beam of high energy. For the treatment of T-lymphomas in children this therapy is usually not used.

Duration of treatment
Treatment of T-cell lymphoma usually lasts for two years. The first part of the treatment lasts for seven months, it is more intense and it includes frequent visits to the hospital, some in the hospital, some outpatients. The second part of the treatment is less intensive, outpatient visits most once a week or two.
In some circumstances lymphoma may be recommended a bone marrow transplant.
Most children with lymphoma may be achieved by complete recovery in chemotherapy or in combination with raditerapy without requiring bone marrow transplantation.

Results of treatment
Modern methods of treatment allow to cure the majority of children with T-cell lymphoma. As the disease can flare up during treatment and after its completion, it is impossible to determine with certainty, whether the child is fully recovered. Five five years after diagnosis must again be tested.

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MALT lymphoma (maltoma)

MALT lymphoma (mucous associated lymphoma tissue) or maltoma – a form of non-Hodgkin’s lymphoma that occurs in about 8%, it is also a third type of lymphoma the most common of all NHL. These forms of lymphoma grow slowly and usually persist for a long time at the site of its origination.

Leading experts on the treatment of diseases of the circulatory and lymphatic systems in Israel are:

Dr. Odelia Gur – a specialist in hematology (blood cancer, lymphoma) and bone marrow transplantation, Head of Department of a day hospital, Ichilov Hospital

Professor Gideon Rechavi – a specialist in the treatment of children’s oncology, brain tumors and leukemia, Director of the Research Cancer Center, Sheba Medical Center, Tel Hashomer

Professor Isaac Yaniv – expert in pediatric oncology and bone marrow transplantation, Director of Hematology Schneider Children’s Hospital
Multi-cell lymphoma develops in lymphatic tissue, mucosal tissues or organs surrounding the abdominal cavity, including organs of the gastrointestinal tract (typically the stomach, but can also occur in the intestine and colon), in the eye tissues, skin, salivary glands, thyroid and breast.

The disease can occur at any age, but usually affects people aged 60 years. Lymphoma is more common in women than in men.

Many people with lymphoma of the stomach infected with Helicobacter Pylori. Bacterial or viral infection are also associated with other forms of lymphoma. Also people who have discovered maltoma often have a history of autoimmune diseases such as Hashimoto’s thyroiditis (thyroid lymphoma), and Sjogren’s syndrome (lymphoma sweat, lacrimal and salivary glands).

Treatment is assigned an experienced diagnostic results and given the stage of the disease and the general condition of the patient.

Most forms of lymphoma develops slowly, localized in one place and respond well to treatment. At the beginning of the treatment, if maltoma stomach is usually assigned local treatment – radiotherapy or surgery. In more advanced stages of MALT lymphoma (stage 3 or 4) is generally assigned systemic treatment – chemotherapy.

Patients with stomach maltoma that were infected with H. Pylori can achieve long periods of remission generally after effective antibiotic treatment. These drugs affect the reduction of lymphoma.

For patients with gastric lymphoma which does not develop the doctor can apply “wait and see” approach.

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